Taxtas 20/Taxtas 80 Caution For Usage

Special precautions for disposal and other handling: Docetaxel is an antineoplastic agent and, as with other potentially toxic compounds, caution should be exercised when handling it and preparing Docetaxel Accord solutions. The use of gloves is recommended.
If Docetaxel concentrate or infusion solution should come into contact with skin, wash immediately and thoroughly with soap and water. If Docetaxel concentrate or infusion solution should come into contact with mucous membranes, wash immediately and thoroughly with water.
Preparation for the intravenous administration: Preparation of the infusion solution: DO NOT use other docetaxel medicinal products consisting of 2 vials (concentrate and solvent) with this medicinal product which contains only 1 vial of concentrate. Docetaxel 20 mg/ml concentrate for solution for infusion requires NO prior dilution with a solvent and is ready to add to the infusion solution.
Each vial is of single use and should be used immediately.
If the vials are stored under refrigeration, allow the required number of boxes of Accord Docetaxel concentrate for solution for infusion to stand below 25°C for 5 minutes before use. More than one vial of Docetaxel (Accord Docetaxel) concentrate for solution for infusion may be necessary to obtain the required dose for the patient. Aseptically withdraw the required amount of Accord Docetaxel concentrate for solution for infusion using a calibrated syringe.
In Docetaxel (Accord Docetaxel) vial, the concentration of docetaxel is 20 mg/ml. The required volume of Docetaxel (Accord Docetaxel) concentrate for solution for infusion must be injected via a single injection (one shot) into a 250 ml infusion bag containing either 5% glucose solution or sodium chloride 9 mg/ml (0.9%) solution for infusion.
If a dose greater than 190 mg of docetaxel is required, use a larger volume of the infusion vehicle so that a concentration of 0.74 mg/ml docetaxel is not exceeded.
Mix the infusion bag manually using a rocking motion.The infusion bag solution should be used within 6 hours below 25°C including the one hour infusion to the patient.
As with all parenteral products, Accord Docetaxel infusion solution should be visually inspected prior to use, solutions containing a precipitate should be discarded. Docetaxel infusion solution is supersaturated and may therefore crystallize over time. If crystals appear, the solution must no longer be used and shall be discarded. Any unused medicinal product or waste material should be disposed of in accordance with local requirements.